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Optimizing Technologies for Discovering Cancer Cell Mutations
Cancer cells often have mutations in their DNA that can give scientists clues about how the cancer started or which treatment may be most effective.
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Special Antibodies Raise Hope of HIV Vaccine
Special antibodies do not just fight one virus strain, but neutralize almost all known virus strains.
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Researchers Unlock Secret of Deadly Brain Cancer's 'Immortality'
Researchers have discovered how a mutation in a gene regulator called the TERT promoter - the third most common mutation among all human cancers and the most common mutation in the deadly brain cancer glioblastoma - confers "immortality" on tumor cells, enabling the unchecked cell division that powers their aggressive growth.
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Tracking the Tumor DNA Trail to Crack the Secrets of Personalized Medicine
Individualised therapies that target the specific genetic features of tumors have the potential to transform cancer diagnosis, treatment and care. However, several challenges still need to be overcome before these approaches can be widely used in the clinic. Two DNA testing programmes have been implemented in institutes in Spain and the UK, to match patient tumor profiles with targets of early clinical trials, and to embed whole genome sequencing (WGS) in routine oncology practice, respectively.
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Number of Stem Cells Actively Making White Blood Cells Quantified in Humans
A 'capture-recapture' genome sequencing technique has enabled the quantification of certain stem cells in humans.
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How Did Psychiatric Disorders Evolve?
How and why human-unique characteristics such as highly social behavior, languages and complex culture have evolved is a long-standing question. A research team led by Tohoku University in Japan has revealed the evolution of a gene related to such human-unique psychiatric traits.
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Why the Whole Genome Matters in Neurodevelopmental Disorders
Whether an individual develops a neurodevelopmental disorder like autism or ADHD and the severity of that disorder depends on genetic changes beyond a single supposedly disease-causing mutation. A new study reveals that the total amount of rare mutations in a person’s genome can explain why individuals with a disease-associated mutation can have vastly different symptoms.
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Stifling 'Staufen1' in Cells Improves Motor Function in Neurodegenerative Mice
Study connecting RNA stress granules with autophagy provides insights on treatment approaches for degenerative ataxia.
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HEAL Helps Detect Heritable Disease Risk
Detecting inherited risk factors for diseases tied to more than a single gene has proved challenging. Now, researchers have used artificial intelligence to predict an individual's risk for developing a complex cardiovascular disease using only his or her genome sequence.
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Epigenetic Control of Memory Strengthening
Scientists report how several particular epigenetic changes in the hippocampus of the rat brain control downstream regulation of translation in brain neurons during fear memory reconsolidation.
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