We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

A New Human Height Inheritance Model

A New Human Height Inheritance Model

A New Human Height Inheritance Model

A New Human Height Inheritance Model

Credit: Daan Stevens/ Pexels
Read time:

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "A New Human Height Inheritance Model"

First Name*
Last Name*
Email Address*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Skoltech scientists and their colleagues have proposed a new human height inheritance model that accounts for the interaction between various factors that influence adult human height. The research was published in the European Journal of Human Genetics.

Human height is a classical quantitative trait that depends on sex, genetics, and the environment.

Scientists from Skoltech, Novosibirsk State University, the Institute of Cytology and Genetics of the Siberian Branch of RAS, and the Institute of Science and Technology in Vienna analyzed the human height distribution across a population and its dependence on sex, genes, and the environment. The team used a huge set of data on over 369,000 U.K. individuals and average male and female heights from various ethnic groups across the world.

The classical human height model assumes the additivity of various factors. The team has shown that the interactions between these diverse factors should be taken into account when studying remote populations or large datasets. For instance, certain genetic variants are assumed to have a greater effect on the height in males than in females. The researchers proposed an alternative model in which the effects of sex, genes, and the environment are multiplied (and not added up) and can be regarded as independent.

“The conventional model would reveal different average heights in centimeters for males and females in each country, while our model straightforwardly shows a difference of 8%. The same goes for the environment and the genes which turned out to have the same relative effect in all the studied populations,” explains Ivan Kuznetsov, a PhD student at the Skoltech Center for Life Sciences (CLS).

Reference: Slavskii SA, Kuznetsov IA, Shashkova TI, et al. The limits of normal approximation for adult height. Eur. J. Hum. 2021:1-10. doi: 10.1038/s41431-021-00836-7

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.