A New Influence on the Nuclear Genome
A salt water marsh, where F. heteroclitus naturally occur. Individuals used in the study were collected in marshes in Mantoloking, NJ. Inset: a male F. heteroclitus. Credit: Douglas Crawford
In a new study, researchers at the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science examined how the interaction of two genomes in animal cells—the mitochondrial and nuclear genomes—interact to affect adaptation of the Atlantic killifish to different temperatures. They showed that although these genomes are separate physical entities, the mitochondrial genome affects the evolution of the nuclear genome, the genetic material responsible for variations in most traits such as hair color and height.
Interactions between these two genomes, which affect everything from health and physiology to fitness, have important consequences for human health and medical interventions such as mitochondrial replacement therapy in embryos.
All animal cells are made up of two genomes, the nuclear genome with 10,000s of protein coding genes and the mitochondrial genome with 13 protein-encoding genes. All 13 genes from the mitochondrial genome interact with approximately 76 nuclear genes in a single metabolic pathway—called the oxidative phosphorylation pathway—that produces nearly all the metabolic energy needed for animal cells. This study found that the interaction between these genomes and the implications on energy production is strong enough that the mitochondrial genome can alter which version of a gene is present in the nuclear genome.
Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial–nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry. Among individuals with two divergent mitochondrial haplotypes (mt-haplotypes), the genome-wide analyses revealed significant differences in nuclear allele frequencies.
“Our results suggest that metabolic fitness is not simply a function of the mitochondria but instead is reliant on mitochondrial–nuclear interactions and therefore important for our understanding of physiology, human health and evolution,” said Doug Crawford, professor of marine biology and ecology at the UM Rosenstiel School.
Extra-Resistant Wheat is Created From New Gene CombinationNews
A new combination of different strains of resistant wheat may help farmers avoid a common fungal disease.READ MORE
Algorithm Unearths Over 1000 Antibiotic Proteins in a Few HoursNews
The algorithm identified 10 times more peptide variations than all previous discoveries combined, aiding the hunt for new antibiotics.READ MORE
Hardiness of Wild Rice Could Assist Commercial Rice GrowersNews
Wild rice growing in northern Australia’s crocodile-infested waters could help boost global food security, say researchers who have mapped its genetic family tree. Valuable traits from the wild rice – such as drought tolerance and pest and disease resistance – can be bred into commercial rice strains.READ MORE