ABI Makes Primer Sequences Available Through NCBI Website
News Jan 13, 2006
Applied Biosystems has announced that it has contributed 400,000 primer-pair designs, that cover nearly 16,000 human genes, to the new probe database developed by the National Center for Biotechnology Information (NCBI) in the US.
These primer sequences, developed for the Applied Biosystems VariantSEQr™ Resequencing System, will allow DNA sequence variants associated with disease and other phenotypes to be detected easily by resequencing.
The freely available Applied Biosystems primer designs include full gene coverage, with primers for all exons (coding and non-coding), intron/exon splice junctions and 5' regulatory regions.
Each gene is annotated to show regions where there is less than 100 per cent coverage and each primer-pair's performance is given a predicted confidence value.
As genome editing technologies advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. However, challenges need to be addressed before potential treatments can be widely used in patients. To tackle these challenges, the National Institutes of Health has launched the Somatic Cell Genome Editing program, which has awarded multiple grants including more than $3.6 million to assess the safety of genome editing in human cells and tissues.