AltheaDx to Offer the DxS K-RAS Test for Clinical Studies
News Nov 05, 2008
DxS Ltd has announced an agreement with US-based Oncology diagnostic and biopharmaceutical services company AltheaDx, Inc., which will provide US study centres with access to DxS’ K-RAS mutation detection assays.
The deal will see AltheaDx use DxS’s K-RAS Mutation Test Kit to support clinical research where cancer patients are assessed for their K-RAS mutation status.
The deal builds on DxS’ continued expansion this year with the exclusive global distribution agreement with Roche earlier this year. The deal also builds on the AltheaDx biomarker development collaboration with BiPar Sciences and Poniard Pharmaceuticals, and reinforces the position of AltheaDx as the premier biopharma partner for signature discovery, and companion diagnostic development.
The DxS K-RAS Mutation Test kit allows clinicians to screen patients for mutations in the K-RAS gene which is mutated in approximately 35-45% of metastatic colorectal cancer, as well as a variety of other cancers.
This year also saw further clinical data announced at the ASCO conference, which has led to a need for colorectal cancer patients to be screened for mutations in the K-RAS gene in order to identify the most appropriate treatment. Patients carrying mutations in the K-RAS gene do not respond to a class of drugs known as EGFR inhibitors – such as Vectibix® and Erbitux®.
Computation and Chemistry Combine to Create World-First Auxetic ProteinNews
A team of chemists at the University of California, San Diego (UCSD) has now designed a two-dimensional protein crystal that toggles between states of varying porosity and density. This is a first in biomolecular design that combined experimental studies with computation done on supercomputers. The research, published in April 2018 in Nature Chemistry, could help create new materials for renewable energy, medicine, water purification, and more.
Fructose Formula Poses Risk to Babies With Metabolic DisorderNews
Babies with inherited intolerance of fructose face a risk of acute liver failure if they are fed certain widely available formulas containing fructose, pediatricians and geneticists are warning. Baby formula manufacturers should remove fructose or sucrose, or explicitly label their products to allow parents to avoid those sweeteners if necessary, the doctors say.
4000-Year Old DNA Helps Track the Spread of Rice Farming in AsiaNews
Rice farming spread far and wide in ancient Southeast Asia, but how it got there has been a mystery. Now, a study of 4000-year-old DNA—a rare find in this region—suggests it came with farmers migrating from China, where rice farming originated.