Artemis Announces Collaboration Agreement with Bristol-Myers
News Mar 01, 2006
Under the agreement Artemis will generate various genetically-engineered murine models carrying selected genetic mutations.
Bristol-Myers Squibb will use these models in its drug discovery research activities for the validation of drug screening targets.
Such targets are used to identify compounds and therapies for the treatment of diseases for various indications in humans.
The generation of the in vivo rodent models will be based on Artemis' proprietary ArteMice™ and ArteMice™ Conditional™ technologies.
These technologies are designed to enable the introduction of genetic sequences containing the CreER gene switch for conditional gene knock out and the creation of humanized conditional mutants in which murine genes are replaced by their human orthologues.
Quality control and transfer will be done together with Artemis' strategic partner company Taconic, which also provides use licenses to Bristol-Myers Squibb covering the U.S. territory for mouse models generated by Artemis, using techniques included in the PNS and Isogenic DNA patents.
Analytical Tool Predicts Disease-Causing GenesNews
Predicting genes that can cause disease due to the production of truncated or altered proteins that take on a new or different function, rather than those that lose their function, is now possible thanks to an international team of researchers that has developed a new analytical tool to effectively and efficiently predict such candidate genes.
Gene Regulator May Contribute to Protein Pileup in Exfoliation GlaucomaNews
Researchers are seeking factors that contribute to protein pileup in exfoliation glaucomaREAD MORE
Single Gene Change in Gut Bacteria Alters Host MetabolismNews
Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice. The research provides an important step towards understanding how the microbiome – the bacteria that live in our body – affects metabolism.READ MORE