Biosearch Technologies Issued Two new Patents
News Mar 09, 2010
Biosearch Technologies, Inc. has announced that it has been awarded U.S. Patent Nos. 7635598 and 7635762. These patents demonstrate Biosearch’s continued commitment to the advancement in the field of pro-fluorescent assays.
“Luminescent Metal Ion Complexes” (US7635762), developed by Ronald Cook, Matthew Lyttle, and Mary Katherine Johansson, describes how a non-traditional fluorophore composed of a metal ion chelate can be efficiently attached to a biomolecule. This technology was used to develop Biosearch’s Pulsar® 650 reporter label, notable for its large Stokes’ Shift (absorption maximum at 450 nm; emission maximum at 650nm).
“Inducible fluorescence assay” (US7635762), developed by Ronald Cook, Eliana Saxon Armstrong, and Hans E. Johansson, describes a novel reporter system based on the use of an azoreductase enzyme to permanently destroy the quenching ability of Biosearch’s BHQ® dyes, thereby activating any linked fluorophore. The versatility of the new assays system in this invention dramatically expands the ability to perform multiplexed, cell-based reporter gene assays used in high throughput screening.
In treating inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn’s disease.