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Biosearch Technologies Issued Two new Patents

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Biosearch Technologies, Inc. has announced that it has been awarded U.S. Patent Nos. 7635598 and 7635762. These patents demonstrate Biosearch’s continued commitment to the advancement in the field of pro-fluorescent assays.

“Luminescent Metal Ion Complexes” (US7635762), developed by Ronald Cook, Matthew Lyttle, and Mary Katherine Johansson, describes how a non-traditional fluorophore composed of a metal ion chelate can be efficiently attached to a biomolecule. This technology was used to develop Biosearch’s Pulsar® 650 reporter label, notable for its large Stokes’ Shift (absorption maximum at 450 nm; emission maximum at 650nm).

“Inducible fluorescence assay” (US7635762), developed by Ronald Cook, Eliana Saxon Armstrong, and Hans E. Johansson, describes a novel reporter system based on the use of an azoreductase enzyme to permanently destroy the quenching ability of Biosearch’s BHQ® dyes, thereby activating any linked fluorophore. The versatility of the new assays system in this invention dramatically expands the ability to perform multiplexed, cell-based reporter gene assays used in high throughput screening.