Biotechnological, Genomics and Systems–Synthetic Biology Revolution: Redesigning Genetic Code for a Pagmatic Systems Medicine
News Mar 21, 2012
Powerful modern technologies, including next-generation sequencing (NGS) and mass spectroscopy (MS), allow for rapid developments in systems biology and syn¬thetic biology. These advances allow for an unprecedented approach for genomics, transcriptomics, epigenomics and proteomics, providing deeper insights into the interactions of genes, proteins and small molecules. Understanding how interact¬ing biological systems regulate functional networks, chromatin, gene expression, signaling pathways and crucial cellular processes is essential for the future of systems medicine. Although these innovative developments are considered pragmatic and funded by governments and industry, here the author discusses the latest advances and challenges in ‘rewiring’ cellular signaling circuits, and redesign¬ing and editing genetic code for a systems medicine-based pragmatic revolution in health.
This article was published online in Expert Review of Medical Devices and is free to access.
Scientists have used machine learning to train computers to see parts of the cell the human eye cannot easily distinguish. Using 3D images of fluorescently labeled cells, the research team taught computers to find structures inside living cells without fluorescent labels, using only black and white images generated by an inexpensive technique known as brightfield microscopy.READ MORE
Back in 2009, researchers identified a herd of Awassi sheep suffering from "day blindness". As that term implies, these sheep were blind during the day (in bright light) but could see at night, in low-light conditions. After identifying the genetic basis of this blindness, researchers have now successfully used gene therapy to restore their daytime vision.READ MORE