Powerful modern technologies, including next-generation sequencing (NGS) and mass spectroscopy (MS), allow for rapid developments in systems biology and syn¬thetic biology. These advances allow for an unprecedented approach for genomics, transcriptomics, epigenomics and proteomics, providing deeper insights into the interactions of genes, proteins and small molecules. Understanding how interact¬ing biological systems regulate functional networks, chromatin, gene expression, signaling pathways and crucial cellular processes is essential for the future of systems medicine. Although these innovative developments are considered pragmatic and funded by governments and industry, here the author discusses the latest advances and challenges in ‘rewiring’ cellular signaling circuits, and redesign¬ing and editing genetic code for a systems medicine-based pragmatic revolution in health.
This article was published online in Expert Review of Medical Devices and is free to access.