Calando Receives FDA Approval for Phase I Clinical Trial Using a Targeted siRNA Nanoparticle Therapeutic
News Apr 22, 2008
Calando Pharmaceuticals has announced that the U.S. Food and Drug Administration (FDA) have approved its investigational new drug application (IND) for lead anti-cancer compound, CALAA-01. The drug candidate is a targeted nanoparticle, comprised of a proprietary, non-chemically-modified siRNA against the M2 subunit of ribonucleotide reductase—a clinically-validated cancer target—formulated with Calando’s proprietary RONDEL™ (RNAi/Oligonucleotide Nanoparticle Delivery) polymer delivery system.
The FDA approval allows the initiation of a Phase I trial that will be conducted at the UCLA Jonsson Cancer Center (UCLA) in Los Angeles, California, and the South Texas Accelerated Research Therapeutics (START) clinic in San Antonio, Texas. It will be led by Drs. Antoni Ribas (UCLA) and Anthony Tolcher (START).
“We are pleased to have received FDA approval of our IND application for CALAA-01,” said Jeremy Heidel, CSO of Calando. “We look forward to initiating a Phase I clinical trial with CALAA-01 that we believe will be the first clinical study using targeted, systemic delivery of siRNA in an oncology setting. The entire Calando team is excited to be at the forefront of this new area for therapeutic development.”
BOC Sciences Continues to Enlarge Its Publication Collection Using BOC Sciences ProductsNews
BOC Sciences continues to add more publication items that used BOC Sciences products in their researches to its already existing collection.READ MORE
Chemists Develop Method to Synthesize Drugs From Renewable PrecursorsNews
Researchers have developed a new approach to the synthesis of benzofurans from cheap raw materials.READ MORE