Charles River Laboratories Implements BioTrove SNP Genotyping System
News Apr 19, 2006
Charles River Laboratories International, Inc. has announces that it has adopted the OpenArray™ SNP Genotyping System from BioTrove. The BioTrove OpenArray platform will be used in Charles River's rigorous genetic quality control process.
Using this high-throughput genotyping platform, Charles River will be able to rapidly analyze thousands of samples for SNP analysis per month, ensuring researchers the congenicity of their inbred and first generation hybrid strains used in biomedical studies.
The OpenArray platform produces thousands of parallel PCR reactions for SNP analysis utilizing standard homogeneous assays. Now, researchers may rapidly test validated SNPs of interest against hundreds or even thousands of DNA samples.
"We have been impressed with the BioTrove OpenArray platform in many ways," said Dr. Bruce Elder, Director of Corporate Rodent Genetics at Charles River Laboratories.
"The BioTrove's flexibility, strong genotyping performance, and throughput capabilities make quality control testing of multiple samples possible using many more genetic markers."
"In addition, the OpenArrays can be formatted in any configuration to provide for future applications."
"We are pleased to be working with a market leader like Charles River. Their implementation of high-throughput sample genotyping will enable them to quickly respond to their customers' needs today with the ability to expand as their genetic testing services continue to grow," said Alan Carter, Chief of Commercial Operations.
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.
Researchers published today a detailed description of the complete genome of bread wheat, the world's most widely-cultivated crop. This work will pave the way for the production of wheat varieties better adapted to climate challenges, with higher yields, enhanced nutritional quality and improved sustainability.