Chimp Genome Helps Scientists Learn More About Human DNA
News Sep 08, 2005
Scientists from Washington University School of Medicine have announced that they have identified changes in the human genetic code by comparing the human genome to the chimpanzee genome and that were so advantageous that they rapidly became the norm throughout humanity.
The areas of human DNA where these changes occurred are currently the subject of follow-up investigations to identify the potentially vital contributions they now make to human health and development.
Scientists detail their initial analysis of the chimp genome, conducted largely in the context of human-chimp comparisons, in the Sept. 1 issue of Nature.
According to the researchers, the chimp genome's remarkable closeness to the human genome will make it a powerful tool for comparative genetics, which uses interspecies comparisons to identify areas of interest in the vast fields of data contained in DNA.
"We're excited about being able to compare our own genetic blueprint with that of our closest living relative," says Richard K. Wilson, Ph.D., director of the Genome Sequencing Center (GSC) at Washington University School of Medicine in St. Louis.
"Over the next few years, such a comparison will allow us to learn more about how our own genome has evolved and gain a better understanding as to why we get cancers and other diseases that chimpanzees very rarely suffer."
Wilson and other scientists at the GSC sequenced half the chimpanzee genome and coauthored the analysis.
Both the chimpanzee and the human genome contain approximately 20,000-25,000 protein-coding genes in 3 billion base pairs of DNA.
The current sequences of the human and chimp genomes are directly comparable over approximately 96 percent of their lengths, and these regions are 99 percent identical.
The initial analysis provides the first detailed look at the genetic changes that prompted the chimp-human species divergence and an intriguing glimpse of how the evolution of both species has continued since that divergence.
Because the chimp and human genomes are so similar, researchers' efforts to uncover genetic roots of the two species' differences will focus not only on the identification of altered or unique genes but also on how largely similar genes are used differently.
Changes in how frequently a protein is made from a particular gene or in the way a gene's protein-building instructions are spliced together can dramatically change the gene's effects.
Scientists suspect such changes in gene usage may be a primary contributor to the differences in chimpanzee and human brains.
An early comparison suggests the added complexity and larger size of the human brain versus the chimp brain owes much less to the development of human genes for brain proteins than it does to changes in the way existing genes are used as the human brain develops.
Since their divergence, areas of rapid genetic change in both species include reproduction, the sense of smell and immunity, all of which are also areas of rapid change for other mammals.
Scientists found several genes for olfactory receptors in chimpanzees had become pseudogenes in humans.
Such genes are still recognizable for the function they once fulfilled but have been disabled through slight changes in their coding.
In both humans and chimps, the tips of the chromosomes typically accumulate mutations much more quickly than the interiors of the chromosomes.
The chimpanzee-human genome comparison revealed approximately 35 million instances of a change of a single character in the DNA code, and 5 million sites where larger changes were present.
Partial or complete deletions had removed or disabled 50 genes, and other types of mutations had disabled a number of additional genes.
Many of the differences were due to disruptive insertions in the genetic code.
Chimpanzee DNA, for example, shows several instances of having incorporated segments from viruses that are often duplicated and reinserted at various points in the genome.
In humans, the Alu element, a non-viral segment of DNA that tends to get copied and inserted around the genome, was a significant source of these changes.
As researchers compare and contrast chimp and human data with other primate and mammalian genomes scheduled for completion in the next few years, they should be able to disregard such areas of change and zero in on the small group of genetic alterations responsible for unique aspects of human nature.
As genome editing technologies advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. However, challenges need to be addressed before potential treatments can be widely used in patients. To tackle these challenges, the National Institutes of Health has launched the Somatic Cell Genome Editing program, which has awarded multiple grants including more than $3.6 million to assess the safety of genome editing in human cells and tissues.