ClearLight Licenses Rights from Stanford University
News Nov 08, 2016
ClearLight Diagnostics, LLC announced that it has signed an exclusive, worldwide license agreement with Stanford University. The license agreement provides exclusive intellectual property rights covering inventions relating to a new microscopy approach called SPED (SPherical-aberration-assisted Extended Depth-of-field) light sheet microscopy as well as for a new RNA interrogation technology developed for multiplexed, volumetric visualization of both long and short RNAs in a variety of intact tissues.
SPED is a conceptually distinct microscopy approach which turns spherical aberration into an advantage by combining the large volumetric field of view of an extended depth of field with the optical sectioning of light sheet microscopy, thereby eliminating the need to physically scan the detection objective for volumetric imaging while maintaining spatial resolution. At the core of SPED light sheet microscopy is a unique and scalable method for extending the depth of field, by building upon the optical mechanisms that induce spherical aberrations.
The RNA interrogation technology licensed by ClearLight is a versatile, high- content, and scalable molecular phenotyping technology of intact tissues that retains RNAs in clarified tissue, coupled with amplification tools for multiplexed detection. Nucleic acid labeling in CLARITY processed tissue may represent an important scientific and clinical opportunity, enabling detection of not only diverse coding RNA variants but also non-coding RNAs. The resulting technology enables measurement of activity- dependent transcriptional signatures, cell-identity markers, and diverse non-coding RNAs in rodent and human tissue volumes.
"We are excited to add these important technologies to our portfolio related to the 3-dimensional interrogation and imaging of tissue samples," said Sarah McCurdy, CEO of ClearLight. "We continue to develop a set of valuable tools and capabilities to support our product development of the CLARITY process."
Story from ClearLight Diagnostics. Please note: The content above may have been edited to ensure it is in keeping with Technology Networks’ style and length guidelines.
Study Reveals How MRSA Infection Compromises Lymphatic FunctionNews
Infections of the skin or other soft tissues with the hard-to-treat MRSA bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. Investigators describe how MRSA infection impairs the ability of lymphatic vessels to pump lymphatic fluid to lymph nodes in mouse models, which may contribute to the frequent recurrences of MRSA infection experienced by patients.
The BuzzBuster: Could Gene Silencing Help Silence the Housefly?News
Gene silencing dsRNA technology can reduce housefly fertility, showing promise as a pest-control method.READ MORE
Researchers Zoom in on DNA Code Being Read in CellsNews
Scientists have unveiled incredible images of how the DNA code is read and interpreted – revealing new detail about one of the fundamental processes of life. The mechanism for reading DNA and decoding it to build proteins for their needs is common to all animals and plants, and is often hijacked by cancer. The discovery of exactly how the molecular mechanism works, could open up new approaches to cancer treatment.READ MORE