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Clontech and Bayer HealthCare Sign Licensing Agreement for High-Throughput Screening Technology
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Clontech, a division of Takara Bio Inc., together with Bayer HealthCare, have announced the completion of a commercial licensing agreement covering the sale of reporter assay kits that use a secreted luciferase isolated by Bayer scientists from the marine copepod, Metridia longa.
Under the terms of the agreement, Clontech was granted a worldwide exclusive license to sell its Ready-To-Glow™ Secreted Metridia Luciferase Systems directly to academic and commercial accounts for use in research and high-throughput screening.
Bayer HealthCare and its affiliates retain the rights to use the technology for in- house screening and diagnostic applications.
This naturally-secreted Metridia luciferase was initially cloned by Bayer scientists for use in drug screening.
It quickly became the perfect choice at Bayer for ultra high-throughput reporter assays, since the cells do not need to be lysed prior to use in a screening assay.
This proved to be a simple and effective way to monitor gene expression or measure reporter gene activity.
The benefits include live cell sampling repeatedly at different time points, high signal intensity and excellent signal stability.
Applications at Bayer include studying the effects of drug/target interactions on signal transduction cascades.
"The key benefits of this novel reporter are that it combines the advantages of a live cell assay with the sensitivity of an enzyme-based system - all in a one-step reaction - by detecting the activity of the secreted reporter enzyme in the media supernatant of transfected cells without the need for cell lysis," said Carol Lou, General Manager of Clontech Laboratories, Inc.
"The utility of this system for high- throughput screening has been effectively demonstrated by Bayer scientists. We are very happy to be able to work with Bayer HealthCare on the commercialization of this exciting technology,"
The products that commercialize this technology are to be sold under the Ready-To-Glow™ family and join an extensive range of products that Clontech provides, including Fluorescent Proteins and other Luminescent Reporter Systems.
