CRISP-Disp Leverages CRISPR-Cas9 to Deliver RNA Structures to Targets in the Genome

News Jun 10, 2015

The method enables the researchers to deliver artificial RNA devices — such as RNA processors, scaffolds, and imaging applications — to specific points on the genome. The work was led by John Rinn who, with his colleagues, is using the approach to better study long, non-coding RNAs (lncRNAs), which are hard to study using traditional knockout methods. With CRISP-Disp, the researchers can relocate lncRNAs to study them in isolation.

To learn more, read the team’s paper, which was published online by the journal Nature Methods.

Unique Gene Mutations in Hereditable Heart Disease

News

Researchers have identified eight new gene mutations that may cause or contribute to idiopathic dilated cardiomyopathy, a form of heart disease not caused by known external influences, such as high blood pressure, obesity, smoking, or diseased coronary arteries.

The Key to a Common Cancer Pathway

News

A team reports the discovery of an unexpected regulator of the critical protein p53, opening the door to the development of drugs that could target it.