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CRISPR Helps Decipher a Congenital Liver Disease

News   May 09, 2019 | Original story from Tokyo Medical and Dental University

 
CRISPR Helps Decipher a Congenital Liver Disease

Congenital hepatic fibrosis (CHF) is a genetic liver disease due to the dysfunction of fibrocystin. In this study, genome-edited human iPS cells are utilized as a disease model of CHF. Fibrocystin dysfunction promotes the proliferation of cholangiocytes in an interleukin-8 (IL-8)-dependent manner, resulting in the bile duct malformation. IL-8 induces progressive liver fibrosis via the promotion of connective tissue growth factor (CTGF) production from cholangiocytes. These pathophysiological mechanisms of CHF are quite different from liver cirrhosis due to chronic hepatitis. Credit: Department of Liver Disease Control TMDU.

 
 
 

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