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DNA Repair After CRISPR Not What We Thought

News   Jul 31, 2018 | Original Press Release from UC Berkeley

 
DNA Repair After CRISPR Not What We Thought

The Fanconi anemia pathway acts as a traffic signal to route repair of double-stranded breaks through two different possible processes: end-joining, which requires no DNA template, and repair that requires a DNA template. As a result, only cells with an active Fanconi anemia DNA repair pathway can repair double-strand DNA breaks by homologous recombination, single-strand template repair or single-strand annealing. Jacob Corn lab, UC Berkeley

 
 
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