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Enabling Personlized Medicine for Minority Populations

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Sanford Health and Nicklaus Children’s Hospital will sequence the genes of nearly 1,000 Latino and Hispanic people in an effort to better understand the health needs of those populations.

To launch the project, philanthropist Denny Sanford and Sanford Health have jointly given $7 million to the Nicklaus Children’s Personalized Medicine Initiative in Miami.

The project is among the many innovative efforts underway at the 289-bed Nicklaus Children’s Hospital, flagship of the Miami Children’s Health System. Founded in 1950, the hospital was rebranded with the Nicklaus name in 2015 in honor of golf icon Jack Nicklaus and his wife Barbara, and in appreciation of the generous support of the Nicklaus Children's Health Care Foundation. The Foundation was created by the Nicklaus family in 2004 to support world-class children’s healthcare in South Florida and nationwide.

“Denny Sanford has been a good friend to Barbara and me for years, but he has been a good friend and passionate supporter of health care and innovative research for even longer,” Jack Nicklaus said. “When we approached Denny with a plea to assist our important work at Nicklaus Children’s Hospital and through our Foundation, he was quick to open his heart and lend a hand. This gift from Denny and Sanford Health will enable groundbreaking research that will hopefully help forever shape pediatric care in South Florida and beyond. On behalf of Barbara and me, and the countless children and families that will be impacted, we can’t thank Denny enough for this incredibly generous gift.”

Genomic medicine focuses on the use of genetic and genomic information to personalize care, in this case, for children. For example, doctors can help determine which therapies or medications work better for individuals once they have some genetic information. It allows physicians to improve treatment outcomes by better understanding the individual characteristics of each patient. The money will help sequence the genes of Hispanic or Latino pediatric patients and their families.

Once the sequencing is done, it will be easier to characterize gene variances and what they mean – including someone’s predisposition to a certain disease or how they might respond to a particular medication. The information can help build a database of common genomes in underrepresented populations and also look for rare diseases.  That will allow researchers to identify genetic patterns among Hispanic and Latino populations, currently a significant gap in genomic medicine.

“Nicklaus Children’s Hospital is committed to offering the most innovative care programs,” said Dr. Narendra Kini, CEO, Miami Children’s Health System (MCHS). “This generous gift allows us to progress our Personalized Medicine Initiative faster and fill a critical need in genetics.   As one of the only personalized medicine programs solely focused on children, this gift will enhance our ability to serve our unique South Florida population and advance care for children throughout Latin America and the world. We are most grateful to Denny Sanford and Sanford Health for their generosity and commitment to creating a better world for children. ”

MCHS is South Florida’s only health care system exclusively for children and includes the nonprofit Nicklaus Children’s Hospital; Miami Children's Health Foundation, the organization's 501 (c)3 fundraising arm; Miami Children’s Research Institute; a network of 10 nonprofit outpatient centers situated in Miami-Dade, Broward and Palm Beach counties; Pediatric Specialists of America, a nonprofit physician practice subsidiary; a management services organization; and an ambulatory surgery center. Nicklaus Children’s Hospital is home to the largest pediatric teaching program in the southeastern United States.

“Bringing these two organizations together will help Sanford diversify its work and research with genomic medicine,” said Kelby Krabbenhoft, president and CEO of Sanford Health. “This is just another example of two health care leaders coming together to pool their knowledge and resources and help drive solutions.”

Sanford Health integrates genetic and genomic medicine into care plans for children, adults, individuals with a cancer diagnosis, and patients with many other conditions. In 2014, a $125 million gift from Denny Sanford created Sanford Imagenetics, a first-of-its kind program that uses genomic medicine to personalize and more effectively deliver primary care for adults. Sanford physicians and researchers also are tailoring treatments based on genetic information for patients who have a variety of diseases, including breast cancer, head and neck cancers, pediatric cancers and heart disease. Genetic counselors - professionals who explore family medical history to better understand inherited conditions - are embedded in clinics across Sanford to educate families.

As the country’s preeminent health care philanthropist, Denny Sanford has given close to $1 billion to Sanford Health in less than two decades. His generosity has spanned across almost every area of care including children’s health, research, breast health and genetics.

This article has been republished from materials provided by Sanford Health. Note: material may have been edited for length and content. For further information, please contact the cited source.