News May 26, 2015
Adolescents who indulge in binge-drinking may alter patterns of gene expression in their still-developing brains, causing long-lasting behavioral changes. To model adolescent binge-drinking in humans, scientists at the University of Illinois at Chicago intermittently exposed 28-day-old rats to alcohol. The rats showed increased anxiety-like behaviors, and they drank more alcohol in adulthood, long after exposure to alcohol had ended. The rats’ amygdalae, the scientists found, contained increased levels of a histone-modifying protein called HDAC2. It causes DNA to coil extra-tightly around histone-complex “spools,” lessening the accessibility of certain genes. One such gene, the scientists indicated appears to be needed for the formation of new synaptic connections.
The tissues in our bodies largely are made of fluid. It moves around cells and is essential to normal body function. In people who have glioblastoma, the deadliest form of brain cancer, this fluid has a much higher pressure, causing it to move fast and forcing cancer cells to spread. Researchers may have found a solution to stopping this inevitable cancer cell spread.READ MORE
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