ERS Genomics, Knudra Transgenics Signs Agreement
News Nov 03, 2016
ERS Genomics Ltd and Knudra Transgenics have announced a non-exclusive license agreement which provides Knudra with worldwide access to ERS’ CRISPR-Cas9 genome editing intellectual property for use in engineering of model organisms. ERS Genomics holds rights to the foundational CRISPR-Cas9 patent portfolio from Dr. Emmanuelle Charpentier, an inventor of the breakthrough gene-editing technology.
Under the license Knudra scientists will use CRISPR technology to engineer C. elegans (commonly known as nematodes or roundworms) and D. rerio (commonly known as zebrafish) to build custom models and develop related products for their customers. Both organisms are used widely as powerful platforms for medical discovery and drug development in both basic research and the pharmaceutical and biotechnology industry.
“Knudra is a young and energetic group of highly-skilled gene editing experts and we are very pleased to provide them with access to the most powerful genome engineering technology available. We believe Knudra is a great example of how a smaller company, dedicated to building platforms for medical discovery, can benefit from use of this exciting new technology.
It is very important to ERS Genomics to provide broad access to the foundational technology and we are focused on enabling as many of these companies as possible to harness CRISPR-Cas9 in multiple areas,” said Eric Rhodes, CEO of ERS Genomics. “CRISPR-Cas9 is a very powerful tool and we are excited to have gained access to this technology through ERS Genomics. We fully expect to see an enhancement to our current genome editing capabilities,” said Dr. Chris Hopkins, CSO of Knudra.
“We look forward to applying CRISPR technology in our TAVASERV Transgenesis Services. We expect the resulting integration will provide significant benefits to our customers’ research needs,” commented Dr. Trisha Brock, CEO of Knudra. Dr. Emmanuelle Charpentier’s research unveiled the key components and mechanisms of the CRISPR-Cas9 system, leading to the landmark publication with Jennifer Doudna, (Jinek, Chylinski et al., 2012), which laid the foundation for the use of CRISPR-Cas9 as a highly versatile and precise genome editing tool.
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.