Experimental Topical Microbicide Offers Long-Lasting Protection Against Genital Herpes Libraries
News Jan 23, 2009
A topical microbicide that silences two genes can safely protect against genital herpes infection for as long as one week, according to a joint study by researchers at the Albert Einstein College of Medicine of Yeshiva University and Harvard Medical School.
The study, carried out in mice and published in Cell Host & Microbe, represents a major step toward developing a vaginal microbicide that offers women convenient, long-lasting protection against herpes infection. Such a microbicide might also help in controlling the AIDS epidemic, since the blisters caused by genital herpes make people more susceptible to HIV infection.
The study’s principal investigators were Deborah Palliser, Ph.D., assistant professor of microbiology & immunology at Einstein and Judy Lieberman, M.D., Ph.D., professor of pediatrics, Harvard Medical School.
An estimated one in five American adults is infected with herpes simplex virus 2 (HSV-2), which causes the sexually transmitted disease known as genital herpes.
The most effective way to prevent the transmission of HSV-2 is to avoid sexual contact during an active outbreak and to use condoms for sexual contact between outbreaks. When an outbreak occurs, promptly taking the suppressive antiviral drug valacyclovir can help minimize symptoms and reduce the risk of transmitting the virus.
The microbicide in this study is based on RNA interference (RNAi), a mechanism cells use to protect their genetic machinery from viruses and other threats. RNAi employs short, double-stranded RNAs called small interfering RNAs, or siRNAs. In 2001, scientists discovered that synthetic siRNAs can induce RNA interference in mammalian cells - a finding that has triggered interest in harnessing this strategy for biomedical research and drug development.
The HSV-2 microbicide used in this study inactivates two genes via RNA interference. One siRNA targets a viral gene, thereby silencing virus immediately following application, but suppression lasts for only a couple of days. The second siRNA - specific for a cell-surface protein used by HSV-2 to dock onto cells it infects - takes a few days to silence the gene, but then confers suppression for a week.
By combining the fast-acting-but-short-lived RNAi with the slower-acting-but-long-lived RNAi, the researchers created a vaginal microbicide offering protection that was both immediate (even warding off an HSV-2 “challenge” given shortly before the microbicide was applied) and sustained (protecting against HSV-2 challenge for a week after application).
“A good microbicide for a sexually transmitted disease must offer long-term protection—compliance will be problematic if it has to be applied immediately before sexual intercourse,” says Dr. Palliser.
She continued, “Our microbicide, with its two siRNAs, provided sustained and uninterrupted protection against HSV-2 infection. And equally important, we achieved these results without causing inflammation of vaginal tissue—a side effect observed with other siRNAs that also risks neutralizing a microbicide’s benefits. We’re hopeful that this experimental microbicide can be turned into a cost-effective therapy for use in developing countries where up to 80 percent of the population is infected with HSV-2.”
The researchers are currently working to refine the microbicide and as yet have no plans for clinical trials.
Research Team Discovers Compound that Stops Cancer From SpreadingNews
Using a mouse model, OHSU physician-scientists lead effort to hone a drug that inhibits cancer cells from spreading to other areas in the body.READ MORE
Mechanism Controlling Multiple Sclerosis Risk IdentifiedNews
Researchers at Karolinska Institutet have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through so-called epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS through the same mechanism.
Synthetic DNA Shuffling Enzyme Outpaces Natural CounterpartNews
A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. Researchers say their lipid-scrambling DNA enzyme is the first in its class to outperform naturally occurring enzymes – and does so by three orders of magnitudeREAD MORE
Comments | 3 ADD COMMENT
Walker Tracy | Jun 05, 2018
I am very much delighted to every viewers that is reading this,i want to inform the whole public of how me and my lover got cured from herpes simplex virus,i was diagnosed of herpes since 3 years ago and also find out that my herpes virus also effected my lover,this Virus started circulating all over our body, and we have also taken treatment from our doctor,few weeks back i came on the net to see if i will be able to get any information as to cure this Virus, on my search i saw various testimony of someone who was healed from herpes simplex virus by the great man called Dr OMOAREBUN and i told my lover about it and without any hesitation, we contacts his mail: email@example.com we wrote him and he guided us,we asked him for solutions and he started the remedies for the both of us and indeed 1 week after me and my lover started using the medicine, we were completely cured no doubt was found on my body and of my lover,so dear viewer why wasting your time living with this STD Virus you can contact him now any kinds of disease,contact his Email firstname.lastname@example.org
Oyelakin Oshuare | May 28, 2018
To cure herpes virus entirely and some other problem, you must understand what causes it, what worsen it and the exactly proven method of getting rid of it. I've been experience it for a long time however it is totally gone now...Check out the following web site for additional information: Dr.Sandy Herpes home on Facebook . Com* Yes Dr.Sandy herbal medicine do work... We gave my sister of his some of his herb (medicine) in 14 days the family doctor. told us how she was doing good. Hypertension his medicine are high but we can't put a price on your body all natural. Thank you Dr.Sandy .. 🙏🙏 you will be missed if you live us.yes I know they will try to kill this new herbal man because he is helping the world and cured thousands of people.....the new young king...and if ever they try to get you don i will still try all for your Legacy to go on.👼✊🙏 and he does a lot of spells such as...Herpes Cure ..ALS Cure..Hiv Cure..Love Spell..Money Spell...Power Spell...Success Spell..Sickness Spell..Pregnancy herbal medicine...Marriage Spell...Job Spell...Protection Spell..Court Case Spell..Luck Spell etc contact his email address. email@example.com firstname.lastname@example.org email@example.com OR call Whats App Number +2349031726182 or facebook posg https://www.facebook.com/Drsandy-SPELL-HOME-2-226270587825982/ Share this plz friends so many people can know about him plz plz...