Foundation Medicine’s Next-Generation Sequencing Data to be Presented at 103rd AACR Annual Meeting 2012
News Mar 28, 2012
Foundation Medicine, Inc. announced that new data highlighting the company’s next-generation sequencing approach in clinical oncology will be presented at the 103rd American Association for Cancer Research (AACR) Annual Meeting 2012 being held March 31 through April 4 in Chicago.
The presentations will highlight the technical feasibility and clinical relevance of the company’s next-generation sequencing platform for oncology, which offers a fully informative genomic profile of the relevant alterations present in about 200 genes known to be somatically altered in human cancers. In these studies, the profile demonstrated concordance with existing commercial offerings and identified all classes of genomic alterations. In one study being presented, approximately 70 percent of cases were found to carry one or more actionable alterations, meaning the alteration could plausibly confer sensitivity or resistance to approved or experimental targeted therapies. The studies also identified more classes of alterations, including base pair mutations, insertions and deletions, copy number alterations and select gene fusions and rearrangements, than other commercially available molecular diagnostic tests.
“The data presented at AACR show that the breadth and relevance of Foundation Medicine’s genomic profile may offer important information for cancer treatment decisions, while fitting easily into routine clinical practice,” said Vincent Miller, M.D., senior vice president, clinical development, Foundation Medicine. “These findings support the feasibility of our fundamental mission to help practicing oncologists integrate the unique molecular information for each patient’s tumor into clinical decision making.”
scNMT-seq Allows Analysis of Connections Between Nucleosomes, Methylation and TranscriptionNews
A new bioinformatics technique allows researchers to study three key processes inside the cell simultaneously.READ MORE
Targeted Drug Could be Used to Treat Advanced Cancers Located Anywhere in the BodyNews
A new targeted drug could be used to treat a small number of advanced cancers no matter where they grow in the body.READ MORE
CRISPR Study Reveals Errors in Earlier Cancer ResearchNews
MELK, a protein previously thought to be implicated in cancer, has been shown to be unrelated to the disease.READ MORE