The 2007 Frost & Sullivan Technology Leadership Award in the European polymerase chain reaction (PCR) reagents market is conferred on Israel-based Do-Coop Technologies Ltd. for its series of nanotechnology-based reagents, which are all based-on the Neowater™, and for their role in enhancing the efficacy of PCR results. The company is also lauded for its consistent market leadership.
A patented nanotechnology procedure enables Neowater™ to mimic the intra cellular properties of water. Neowater™ exhibits hydrophobic and hydrophilic properties, and is fundamentally a water solution with hydrated particles that reduce its entropy.
"Since it is ready to use and is water-based, it offers complete stability over the long-term and does not require any specific temperature maintenance," notes Frost & Sullivan Research Analyst G. Haripriya.
"Among its key benefits are user-friendliness, ease-of-use, cost-effectiveness, an environmentally safe profile and the ability to yield repeatable results," said Haripriya.
In addition to being used as a reagent, Neowater™ can be used as a biocatalyst, media growth enhancer, solvent and buffer. It can be boiled, autoclaved, sheared, filtered, frozen and also shipped and stored at room temperature.
The advantage of Neowater™ is that it can provide a better physical environment for chemical reactions without altering it. The addition of Neowater™ requires minimal alterations in the laboratory procedure but the results that are delivered are voluminous.
"In some places, Neowater™ is used as a replacement for solvents which are alcohol and detergent-based while, at times, it is also used as a reformulation substitute to reduce the toxicity of drugs," adds Ms. Haripriya. "Neowater™ can also be used as a substitute for conventional buffers to avoid issues related to viscosity."
The PCR enhancement is due to the mechanism of action behind Neowater™, namely, that it hydrates molecules and locally concentrates them even when inside other buffers or normal water. The product is also cost effective and can be easily used in many types of sub-optimal and inefficient reactions.
"Neowater™ used for PCR enhances the PCR yield and sensitivity and can also reduce the total PCR volume," says Ms. Haripriya. "It also can improve the reaction specificity and thereby reduce the length and number of cycles of the PCR reaction."