Gene Study Shows How Sheep First Separated from Goats
News Jun 07, 2014
Scientists have cracked the genetic code of sheep to reveal how they became a distinct species from goats around four million years ago.
The study is the first to pinpoint the genetic differences that make sheep different from other animals.
The findings could aid the development of DNA testing to speed-up selective breeding programmes, helping farmers to improve their stocks.
The research identifies the genes that give sheep their fleece and uncovers features of their digestive system, which makes them so well-suited to a diet of low quality grass and other plants.
It also builds the most complete picture yet of sheep's complex biology. Further studies using this resource could reveal new insights to diseases that affect sheep.
Researchers from the University of Edinburgh's Roslin Institute, which receives strategic funding from the Biotechnology and Biological Sciences Research Council, were part of a global team that has decoded the genome sequence - the entire genetic make-up - of domestic sheep for the first time.
This team - the International Sheep Genomics Consortium - compared the sheep's genes with those of other animals - including humans, cattle, goats and pigs.
The analysis identifies several genes that are associated with wool production. It also reveals genes that underpin the evolution of the rumen - a specialized chamber of the stomach that breaks down plant material to make it ready for digestion.
This collaborative study, involving 26 research institutions in eight different countries, was led by researchers from the Commonwealth Scientific and Industrial Research Organization, Australia; BGI and the Kunming Institute of Zoology, China; Utah State University and Baylor College of Medicine in the US; and The Roslin Institute.
The BBSRC-funded ARK-Genomics facility - which is part of Edinburgh Genomics at the University of Edinburgh - provided a substantial body of sequence data, including information on which genes are expressed in a spectrum of 40 different tissues.
The study is published in the journal Science.
Professor Alan Archibald, Head of Genetics and Genomics at The Roslin Institute, said: "Sheep were one of the first animals to be domesticated for farming and are still an important part of the global agricultural economy. Understanding more about their genetic make-up will help us to breed healthier and more productive flocks."
Bioethics Council Rules Heritable Genome Editing "Ethically Acceptable" In Certain CircumstancesNews
A leading UK bioethics advisory body has weighed in on the debate around human genetic modification, concluding that heritable genome editing – modifying the DNA of an egg, sperm or embryo with changes that will be passed on to future generations – could be ‘morally permissible’ in humans, provided key ethical tests are met.
Getting to Know the Microbes that Drive Climate ChangeNews
A new understanding of the microbes and viruses in the thawing permafrost in Sweden may help scientists better predict the pace of climate change.READ MORE
Hay Fever Risk Genes Overlap with Autoimmune DiseaseNews
In a large international study involving almost 900,000 participants, researchers from the University of Copenhagen and COPSAC have found new risk genes for hay fever. It is the largest genetic study so far on this type of allergy, which affects millions of people around the world.READ MORE