We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Rectangle Image
News

Gene Switch May Repair DNA and Prevent Cancer

Rectangle Image
News

Gene Switch May Repair DNA and Prevent Cancer

Read time:
 

They also found that a family of recently discovered enzymes, called TETs for short, is important in maintaining 5hmC's reparative role.

To turn genes on or off, a methyl group can be added to or removed from DNA. During the removal of this chemical tag, called demethylation, the methyl group is converted to 5hmC as an intermediate step. The TET enzymes are thought to be critical to the demethylation process. Recent research has shown that 5hmC is associated with an "opening up" of nearby chromatin, the tightly packaged assembly of proteins and DNA in the cell nucleus.

The team reveals that 5hmC localizes near breaks in DNA that develop naturally or that are caused by DNA-damaging drugs or irradiation. They also found that inhibiting TET enzymes in cells resulted in a lack of 5hmC, followed by errors in chromosome separation. This suggests that TET enzymes are important for the production of 5hmC at DNA damage sites and that both play critical roles in responding to DNA damage.

The research raises the possibility that 5hmC helps to keep chromatin "open" so it can be more accessible to other DNA damage response proteins. 5hmC could be used as a marker for DNA damage, say the researchers.

"Our results imply that loss of TET enzymes and 5hmC depletion could contribute significantly to genome instability and inaccurate chromosome segregation, perhaps explaining the correlation of low 5hmC levels with cancer," say the researchers.

Advertisement