GENEART Receives Major Contract from the Wellcome Trust Sanger Institute
News Nov 26, 2008
GENEART AG announces the closing of a major contract with the Wellcome Trust Sanger Institute, UK. GENEART will synthesize up to 600 tailor-made genes for the Wellcome Trust Sanger Institute's research program under this contract. The genes will be used to identify mechanisms involved in defined genetic and infectious disease. The terms of the agreement were not disclosed.
"We are very pleased that GENEART was selected for this project by the Wellcome Trust Sanger Institute during a tendering process. This emphasizes yet again our leading position in the market for gene synthesis. Worldwide largest capacities and our broad service portfolio allow us to meet specific customer requirements, even for large-scale contracts, in the shortest periods of time", stated Prof. Dr. Ralf Wagner, CEO of GENEART AG.
The program of research at the Wellcome Trust Sanger Institute uses large-scale technologies to understand the role of genes in health and disease and create lasting resources for biomedical research. By developing high throughput technologies to detect networks of extracellular protein interactions, the institute has identified new signaling pathways important for vertebrate development.
The Wellcome Trust Sanger Institute is now expanding the program of research to identify novel human extracellular receptor-ligand interactions involved in genetic diseases such as cardiovascular disease and also infectious diseases.
This program of research will involve screening for interactions within protein libraries that constitute the cell surface receptor repertoire of differentiated human blood cells, and also some pathogens. The protein libraries will also be used to determine the functional consequences of the identified interactions in cell-based assays.
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.