We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Genes Required for Learning and Memory Originated 650 Million Years Ago

A 3D model of a human brain.
Credit: Robina Weermeijer / Unsplash.
Listen with
Register for free to listen to this article
Thank you. Listen to this article using the player above.

Want to listen to this article for FREE?

Complete the form below to unlock access to ALL audio articles.

Read time: 1 minute

A team of scientists led by researchers from the University of Leicester have discovered that the genes required for learning, memory, aggression and other complex behaviours originated around 650 million years ago.

The findings led by Dr Roberto Feuda, from the Neurogenetic group in the Department of Genetics and Genome Biology and other colleagues from the University of Leicester and the University of Fribourg (Switzerland), have now been published in Nature Communications.

Dr Feuda said: “We’ve known for a long time that monoamines like serotonin, dopamine and adrenaline act as neuromodulators in the nervous system, playing a role in complex behaviour and functions like learning and memory, as well as processes such as sleep and feeding.

Want more breaking news?

Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.

Subscribe for FREE

“However, less certain was the origin of the genes required for the production, detection, and degradation of these monoamines. Using the computational methods, we reconstructed the evolutionary history of these genes and show that most of the genes involved in monoamine production, modulation, and reception originated in the bilaterian stem group.

“This finding has profound implications on the evolutionary origin of complex behaviours such as those modulated by monoamines we observe in humans and other animals.”

The authors suggest that this new way to modulate neuronal circuits might have played a role in the Cambrian Explosion – known as the Big Bang - which gave rise to the largest diversification of life for most major animal groups alive today by providing flexibility of the neural circuits to facilitate the interaction with the environment.

Dr Feuda added: “This discovery will open new important research avenues that will clarify the origin of complex behaviours and if the same neurons modulate reward, addiction, aggression, feeding, and sleep.”

Reference: Goulty M, Botton-Amiot G, Rosato E, Sprecher SG, Feuda R. The monoaminergic system is a bilaterian innovation. Nat Commun. 2023;14(1):3284. doi: 10.1038/s41467-023-39030-2

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.