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Genome of a Third Neanderthal Sequenced

Genome of a Third Neanderthal Sequenced content piece image
Researchers have sequenced the genome of a Neandertal from Chagyrskaya Cave in the Altai Mountains to high quality. Credit: Dr. Bence Viola, Dept. of Anthropology, U. of Toronto.
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Until now, only the genomes of two Neanderthals have been sequenced to high quality: one from Vindjia Cave in modern-day Croatia and one from Denisova Cave in Siberia’s Altai Mountains. A research team led by Svante Pääbo from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, has now sequenced the genome of a third Neanderthal whose remains were found - 106 kilometres away from the latter site - in Chagyrskaya Cave.

The researchers extracted the DNA from bone powder and sequenced it to high quality. They estimate that the female Neanderthal lived 60,000-80,000 years ago. From the variation  in the genome they estimate that she and other Siberian Neanderthals lived in small groups of less than 60 individuals. The researchers also show that the Chagyrskaya Neanderthal was more closely related to the Croatian than to the other Siberian Neanderthal which lived some 40,000 years before the Chagyrskaya Neanderthal. This shows that Neanderthal populations from the West at some point replaced other Neanderthal populations in Siberia.

"We also found that genes expressed in the striatum of the brain during adolescence showed more changes that altered the resulting amino acid when compared to other areas of the brain", says Fabrizio Mafessoni, lead author of the study. The results suggest that the striatum - a part of the brain which coordinates various aspects of cognition, including planning, decision-making, motivation and reward perception - may have played a unique role in Neanderthals.

Reference: Mafessoni et al. (2020). A high-coverage Neandertal genome from Chagyrskaya Cave. PNAS. DOI: https://doi.org/10.1073/pnas.2004944117.

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