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Helicos BioSciences Announces Genome Sequencing Using True Single Molecules

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Helicos BioSciences has announced that it has sequenced the M13 genome, by utilizing its non-amplified True Single Molecule Sequencing (tSMS™) technology in conjunction with its SimplePrep™ genome preparation technique.

Sequencing of M13 was conducted on the entire genome, including so-called homopolymeric sequences.

"This marks an unprecedented achievement," said Stanley N. Lapidus, President and CEO of Helicos BioSciences.

"Helicos is the only organization to have successfully sequenced a genome using tSMS™ technology - an accomplishment we've worked hard to achieve."

He added, "The simplicity of tSMS™ in working directly from genomic DNA and eliminating amplification, provides researchers with unparalleled advantages, potentially enabling them to represent the entire human genome on a single glass substrate - and to sequence it in a day, and not years."