Highly Prestigious Grant Awarded to Study how Damaged DNA is Managed by Cells
News Mar 22, 2013
The €2.5 million award will enable Prof. Ulrich to develop cutting edge methods and approaches with which to study the mechanism that allows cells to accurately replicate even though their DNA is damaged.
When DNA is replicated it is vulnerable to decay; the ability of cells to deal with this stress is a major factor in protecting our genomes from instability and cancer. A key mechanism allowing cells to overcome such damage is DNA damage bypass and post-replication repair. However, this process has to be very tightly regulated as it can itself lead to genomic instability if not correctly controlled. Prof. Ulrich will investigate how this regulation occurs by developing new methods and technologies that will allow her to introduce DNA damage at specific locations in cell genomes. How this damage is processed will subsequently be imaged in live cells.
Particular attention will be paid to determining how post-translational modifications of the DNA-clamp protein PCNA coordinate the process of post-replication repair in conjunction with other interacting proteins. The award will fund this research for five years and will support a total of three postdoctoral researchers, two PhD students and a technician.
As part of the project, new methodology will be explored to introduce DNA damage site-specifically into the genome of budding yeast cells. A fusion of green fluorescent protein (GFP) to the bacterial TetR protein marks an array of damaged sequences within yeast nuclei.
Genes Can Influence the Mutation, Activity of Nearby GenesNews
Study shows that a gene’s neighborhood can influence whether and how the activity of a gene changes.READ MORE
Brain Regions Implicated in Mental Disorders Influenced by Neanderthal GenesNews
Findings indicate that the more a person’s genome carries genetic vestiges of Neanderthals, the more certain parts of his or her brain and skull resemble those of humans’ evolutionary cousins that went extinct 40,000 years ago.READ MORE
Acquisition Sees Agilent Gain Powerful NGS IP PortfolioNews
Agilent Technologies announces its acquisition of the molecular and sample barcoding portfolios of Population Genetics Technologies.READ MORE
Comments | 0 ADD COMMENT
International Conference on Genomics and Pharmacogenomics
Jul 18 - Jul 19, 2018
EMBL Course: Next Generation Sequencing: RNA Sequencing Library Preparation
Apr 23 - Apr 27, 2018
EMBO Practical Course: Microbial Metagenomics: A 360º Approach
Apr 23 - Apr 30, 2018