Horizon Discovery and DxS to Lead the Way in Setting Standards for Companion Diagnostic Tests
News Jul 24, 2009
Horizon Discovery (Horizon) and DxS Limited, two UK companies promoting the development, approval and sale of companion diagnostic products, have announced a strategic collaboration that will see Horizon develop a panel of human isogenic cell models that recapitulate key drug sensitivity and resistance mechanisms in cancer patients that will be used to further develop DxS’ TheraScreen® range of clinical diagnostic kits.
Using a proprietary gene-engineering technology called GENESIS™, Horizon will generate a range of ‘X-MAN™’ (Mutant And Normal) cell-lines as a source of high-quality, genetically-defined human DNA that will be specifically used to assess the performance of DxS’ TheraScreen: K-RAS Mutation Kits. These kits enable clinicians to ascertain which patients will respond to anti-EGFR targeted colorectal cancer treatments including Erbitux™ and Vectibix™ based on K-RAS mutation status.
The American Society of Clinical Oncologists (ASCO) is similarly petitioning for the same guidelines to be adopted in the U.S. Current estimates indicate that approximately $750 million/year of savings will be conferred onto taxpayers and healthcare re-imbursers by the prescription of EGFR-drugs only to patients with a non-mutated K-RAS gene, who will benefit from the drugs.
Dr Chris Torrance, CEO of Horizon said “we are entering an age where we have enough information to have a significant impact on treating cancer. It now comes down to the time and money it currently takes to find and tailor new targeted treatments, it is Horizon’s mission to better coordinate all the stakeholders and regulators in the drug discovery process, such as the FDA, NIST and EMEA, to find ways of speeding this process up.”
“Our initial focus will be on evaluating new diagnostic kits from DxS using isogenic human mutant vs. normal DNA-controls, which we feel represent a ‘gold-standard’ means of bench-marking companion diagnostics where mutations often need to be detected in humans within a background of excess isogenic normal DNA.
Horizon and DxS share a vision for personalized medicine and are leading the world in providing critical new tools that will enable a future where cancer patients will be screened for the genetic changes that drive their disease and then given the most effective targeted treatments to combat them.
Financial terms of the agreement were not disclosed.
In treating inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn’s disease.