Horizon Discovery Sign Screening Agreement with Actelion Pharmaceuticals
News Dec 18, 2008
Horizon’s X-MAN (Mutant And Normal) cell-line technology provides the first genetically defined and patient-relevant in vitro models of human cancer. These models are being used by a growing number of Pharma and Biotech companies to rationalize key steps of the ‘targeted’ drug development process, and thus accelerate and economize the burgeoning field of ‘personalized’ medicine.
The agreement covers the screening of a number of Actelion lead compounds on a wide panel of genotypes. The approach should enable Actelion to predict; the selectivity of their compounds against representative patient genotypes; drug resistance mechanisms conferred by secondary mutations and; the patient groups most likely to respond in clinical trials.
Dr Darrin M Disley, Commercial Director of Horizon says “working with Actelion is an exciting development for Horizon as they already have experience of working with isogenic models in oncology research and development programs. In this expandable agreement, we hope to further prove the potential of our human X-MAN models in a screening environment; thus facilitating a long and productive relationship with Actelion”
Actelion will pay Horizon undisclosed fees during the term of the agreement. Work between the parties will begin in January 2009.
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.
Researchers published today a detailed description of the complete genome of bread wheat, the world's most widely-cultivated crop. This work will pave the way for the production of wheat varieties better adapted to climate challenges, with higher yields, enhanced nutritional quality and improved sustainability.