Iconix Extends Toxicogenomics Gene Expression Database to Affymetrix GeneChip® Platform
News Mar 07, 2006
Iconix Pharmaceuticals, Inc. has announced a major extension of its DrugMatrix® toxicogenomic database to include a large addition of data generated by the Affymetrix GeneChip® platform at the Society of Toxicology Annual Meeting.
The two companies recently signed a collaborative agreement to develop solutions to aid in the study of the toxicological and pharmacological properties of drugs and drug candidates.
According to Iconix, extension of the DrugMatrix database is a key step in this collaboration and will further researchers' ability to effectively prioritize drug candidates and to make decisions earlier in the drug development process.
"The addition of whole genome toxicology information from experiments run on the Affymetrix platform is a major milestone in advancing development of new solutions that will aid in the safety screening of candidate compounds," said Don Halbert, Ph.D., executive vice president of Research and Development at Iconix Pharmaceuticals.
"Equally important, by extending DrugMatrix to include the Affymetrix platform, we are greatly expanding the accessibility and utility of the database."
"We are pleased that Iconix has chosen to add whole genome array data generated by our GeneChip microarray platform to its DrugMatrix database," said Lianne McLean, senior director, Gene Expression Marketing at Affymetrix.
"This information will accelerate toxicogenomic research by helping scientists prioritize compounds at the earliest possible stages."
The DrugMatrix expansion adds data for hundreds of compound treatments in liver, kidney, heart and cultured primary rat hepatocytes. The database now includes data generated by the Affymetrix GeneChip RG-230 2.0 Array.
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.
Researchers published today a detailed description of the complete genome of bread wheat, the world's most widely-cultivated crop. This work will pave the way for the production of wheat varieties better adapted to climate challenges, with higher yields, enhanced nutritional quality and improved sustainability.