Icoria Receives Phase II SBIR Contract for Liver Injury Biomarkers
News Oct 21, 2005
Icoria, Inc. has announced that it had received a Small Business Innovation Research (SBIR) contract from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, worth close to $800,000.
The Phase II contract supports the application of metabolomics and gene expression analysis in the study of alcohol-related diseases, including liver and brain injury, in a study program entitled, “Metabolomics: Alcohol Induced Toxicity.”
The contract is the second Phase II SBIR contract Icoria has been awarded this year. The company previously announced the receipt of a separate $1.2 million SBIR contract in a Current Report on Form 8-K and press release issued August 29, 2005.
“Together, the two Phase II SBIR contracts help to support our biomarker discovery efforts on a broad set of liver pathologies that span a variety of mechanisms,” said Thomas Colatsky, Ph.D., Icoria’s Chief Scientific Officer.
“By using metabolomics and gene expression to analyze different forms of liver toxicity, we hope to identify new biomarkers for liver disease that should have utility in the development of highly-informative, minimally invasive diagnostics covering acute as well as more chronic liver-related diseases, including alcoholic and non-alcoholic fatty liver disease.”
In June 2004, Icoria announced Phase I of this contract, which was undertaken in collaboration with the Bowles Center for Alcohol Studies at the University of North Carolina-Chapel Hill School of Medicine.
In Phase I, Icoria used metabolomics to identify key biochemicals in the liver, brain and plasma that correlated with changes in tissue pathology.
Phase I of the contract was completed in March of this year. After reviewing the results, the NIAAA approved Phase II of the contract.
Phase II will extend the Phase I findings to include gene expression analysis in liver, brain and whole blood.
Icoria will probe this rich and expanded data set to identify biomarkers of liver and brain toxicity and to explore mechanisms involved in both alcohol dependence and withdrawal.
Computation and Chemistry Combine to Create World-First Auxetic ProteinNews
A team of chemists at the University of California, San Diego (UCSD) has now designed a two-dimensional protein crystal that toggles between states of varying porosity and density. This is a first in biomolecular design that combined experimental studies with computation done on supercomputers. The research, published in April 2018 in Nature Chemistry, could help create new materials for renewable energy, medicine, water purification, and more.
Fructose Formula Poses Risk to Babies With Metabolic DisorderNews
Babies with inherited intolerance of fructose face a risk of acute liver failure if they are fed certain widely available formulas containing fructose, pediatricians and geneticists are warning. Baby formula manufacturers should remove fructose or sucrose, or explicitly label their products to allow parents to avoid those sweeteners if necessary, the doctors say.
4000-Year Old DNA Helps Track the Spread of Rice Farming in AsiaNews
Rice farming spread far and wide in ancient Southeast Asia, but how it got there has been a mystery. Now, a study of 4000-year-old DNA—a rare find in this region—suggests it came with farmers migrating from China, where rice farming originated.