Improved Path to Cassava Production
News Apr 19, 2016
A new analysis of the genetic diversity of cassava will help improve strategies for breeding disease resistance and climate tolerance into the root crop, a staple and major source of calories for a billion people worldwide.
Reported in the journal Nature Biotechnology, the UC Berkeley-led project involved scientists from the U.S. Department of Energy Joint Genome Institute and Monash University in Australia.
In the paper, the team, led by Daniel Rokhsar, a UC Berkeley professor of molecular and cell biology and of physics, compared the cassava reference genome to the genomes of its relatives: the castor bean, rubber tree, Ceara rubber and 53 cultivated and wild cassava varieties from around the world.
They found that the genetic diversity of cassava used in current breeding efforts has been greatly reduced in Africa, where viruses such as the cassava mosaic disease and the cassava brown streak disease have affected crop yields in many countries. They were able to detect the genetic signature of past cassava improvement programs going back to the 1930s, which interbred cassava and Ceara rubber, and the persistence of these Ceara rubber regions in elite cassava varieties suggests they confer desirable traits.
They also mapped out how the many cultivated cassava varieties are related, which can help breeders maximize genetic diversity in improvement programs.
“The variants and population structure described here are essential inputs for marker-assisted and genome selection-based approaches to improving disease resistance and yield for this staple crop,” noted the team, which included UC Berkeley specialist Jessen Bredeson and postdoctoral scholar Jessica Lyons.
Cassava root is easy to grow and has a high starch content – between 20 and 40 percent by weight – which makes it an ideal source of calories. However, it is particularly vulnerable to plant pathogens, which can significantly reduce crop yields.
The root crop also represents a strategic source of renewable energy — as biomass from which ethanol is being produced for transportation fuels. With the help of genomics, researchers hope to apply advanced breeding strategies that can improve cassava’s resistance to diseases and improve crop yields, Rokhsar said.
The work was funded by the Bill and Melinda Gates Foundation, the U.K. Department for International Development and the NEXTGEN Cassava Breeding project. Co-authors include former UC Berkeley doctoral student Eric Edsinger-Gonzales, now at the Okinawa Institute of Science and Technology Graduate University, and UC Berkeley undergraduate Cindy Ha.
Children who are genetically predisposed to overweight, due to common gene variants, can still lose weight by changing their diet and exercise habits. Around 750 children and adolescents with overweight or obesity undergoing lifestyle intervention participated in the study conducted by researchers from the University of Copenhagen and Holbæk Hospital.
6th World Congress on Human Genetics and Genetic Diseases
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