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Institute for Systems Biology Completes Purchase of Cyntellect LEAP™ System

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Cyntellect, Inc. has announced that the Institute for Systems Biology (ISB) has completed the purchase and installation of Cyntellect's Laser- Enabled Analysis and Processing (LEAP) system in its Seattle, Washington facility. ISB plans to exploit LEAP's in situ live cell manipulation capabilities to enable new approaches to functionally cloning immune cells and determining their potential roles in mediating disease.

"LEAP is an exciting new technology that will facilitate many different aspects of systems approaches to disease" stated Dr. Leroy Hood, President of ISB.

LEAP is an automated live-cell manipulation system that combines high- speed optical imaging of cells (brightfield or fluorescence), real-time image analysis with high-speed in situ laser manipulation of live cells.

Using LEAP, researchers have demonstrated: (i) accelerated functional cloning of cells, including highly-secreting cells for biopharmaceutical manufacturing purposes, (ii) image-based cell purification of adherent and non-adherent cell types and (iii) laser-based macro molecule delivery, including siRNA, small molecules, proteins and quantum dots.

"ISB is an institute well-known for performing high-quality research to define, understand and resolve the mechanisms of cellular diseases," stated Dr. Fred Koller, Cyntellect's President and CEO. "ISB's appreciation for the unique role LEAP can play in this process is testimony to the potential for in situ live-cell processing and we are proud to have ISB as a customer."

ISB's LEAP purchase was supported in part through grant S10 RR023639-01, awarded to ISB by the NIH's National Center for Research Resources under their Shared Instrumentation Grant Program.