Integrated Lead Discovery: An Evolving Toolbox
A new SLAS Discovery review article offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.
While high-throughout screening (HTS) remains a mainstay in drug discovery, other approaches have emerged or evolved in the past decade that offer complementary strengths and weaknesses, and are increasingly applied in combination with, or in lieu of, HTS. Great success often can be achieved by combining different approaches in an integrated manner.
Leveridge et al. survey the landscape of lead discovery tactics that researchers use today and explain how this toolbox of approaches is evolving as new science emerges, such as in the areas of complex cellular models and computational techniques. Case studies illustrate how integration of techniques like DNA-encoded library screening (ELT) and HTS, phenotypic and target-based screening, and virtual screening (VS) with experimental approaches can lead to successful outcomes and provide insights and synergies that would never have been obtained through one technique alone.
Integration of Lead Discovery Tactics and the Evolution of the Lead Discovery Toolbox can be accessed for free for a limited time at http://journals.sagepub.com/doi/full/10.1177/2472555218778503.
This article has been republished from materials provided by SLAS. Note: material may have been edited for length and content. For further information, please contact the cited source.
Hunger Hormones: A Promising Avenue for Addiction Treatment?News
Hormones that signal the body's state of hunger and fullness could be the key to new treatments for drug and alcohol addiction. Researchers expressed optimism about the potential for rapid progress toward new addiction treatments, since several drugs that affect these hormones are already approved or in the FDA pipeline.READ MORE
Chili Pepper Derived Anti-Obesity Drug Shows Promise in Animal TrialsNews
A novel drug based on capsaicin, the compound that gives chili peppers their spicy burn, caused long term weight loss and improved metabolic health in mice eating a high fat diet.READ MORE