Isolation of a new Gene Family Essential for Early Development
News Aug 23, 2007
SOURCE: University of Copenhagen
Researchers at BRIC, University of Copenhagen, have identified a new gene family (UTX-JMJD3) essential for embryonic development. The family controls the expression of genes crucial for stem cell maintenance and differentiation, and the results may contribute significantly to the understanding of the development of cancer.
The results are published in the current issue of Nature, and it follows up on 2 other high-impact articles on related gene families published in Nature and Cell by the same research group within the last year.
How embryonic stem cells work:
All organisms consist of a number of different cell types each producing different proteins. The nerve cells produce proteins necessary for the nerve cell function; the muscle cells proteins necessary for the muscle function and so on. All these specialised cells originate from the same cell type – the embryonic stem cells. In a highly controlled process called differentiation, the stem cells are induced to become specialised cells.
New gene family:
The BRIC researchers have now identified a new gene family, which by modifying gene expression is essential for the regulation of the differentiation process. These results have been obtained by using both human and mouse stem cells, as well as by studying the development of the round worm, C. elegans.
The new findings are in line with a number of recent publications that support the idea that differentiation may not entirely be a “one-way process”, and may have impact on the therapeutic use of stem cells for the treatment of various genetic diseases such as cancer and Alzheimers disease.
Researchers Discover Mutation That Appears to Protect Against Multiple Aspects of Biological AgingNews
The first genetic mutation that appears to protect against multiple aspects of biological aging in humans has been discovered in an extended family of Old Order Amish living in the vicinity of Berne, Indiana, report Northwestern Medicine scientists.READ MORE
Defects in Cell’s ‘Waste Disposal System’ Linked to Parkinson’sNews
An international study has shed new light on the genetic factors associated with Parkinson’s disease, pointing at a group of lysosomal storage disorder genes as potential major contributors to the onset and progression of this common neurodegenerative disorder.READ MORE
Mouse Model Demonstrates Potential of New Autism DrugNews
Scientists have performed a successful test of a possible new drug in a mouse model of an autism disorder. The candidate drug, largely corrected electrical, behavioral and brain abnormalities in the mice.READ MORE