We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Japanese Encephalitis Virus Infection Induces Changes of mRNA Profile of Mouse Spleen and Brain
News

Japanese Encephalitis Virus Infection Induces Changes of mRNA Profile of Mouse Spleen and Brain

Japanese Encephalitis Virus Infection Induces Changes of mRNA Profile of Mouse Spleen and Brain
News

Japanese Encephalitis Virus Infection Induces Changes of mRNA Profile of Mouse Spleen and Brain

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "Japanese Encephalitis Virus Infection Induces Changes of mRNA Profile of Mouse Spleen and Brain"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

RESULTS
The results of microarray analysis showed that 437 genes in spleen and 1119 genes in brain were differentially expressed in response to JEV infection, with obviously upregulated genes like pro-inflammatory chemokines and cytokines, apoptosis-related proteases and IFN inducible transcription factors. And the significant pathways of differentially expressed genes are involved in cytokine-cytokine receptor interaction, natural killer cell mediated cytotoxicity, antigen processing and presentation, MAPK signaling, and toll-like receptor signaling, etc. The differential expression of these genes suggests a strong antiviral response of host but may also contribute to the pathogenesis of JEV resulting in encephalitis. Quantitative RT-PCR (RT-qPCR) assay of some selected genes further confirmed the results of microarray assay.

CONCLUSIONS
Data obtained from mRNA microarray suggests that JEV infection causes significant changes of mRNA expression profiles in mouse spleen and brain. Most of differentially expression genes are associated with antiviral response of host, which may provide important information for investigation of JEV pathogenesis and therapeutic method.

Advertisement