We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
JAX Recieves $28.3M of NIH Funding for Knockout Mouse Project
News

JAX Recieves $28.3M of NIH Funding for Knockout Mouse Project

JAX Recieves $28.3M of NIH Funding for Knockout Mouse Project
News

JAX Recieves $28.3M of NIH Funding for Knockout Mouse Project

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "JAX Recieves $28.3M of NIH Funding for Knockout Mouse Project"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

JAX Professor and Janeway Distinguished Chair Robert Braun, Ph.D., is the principal investigator of the grant, with co-investigators Stephen Murray, Ph.D., and Karen Svenson, Ph.D.

“Mice and humans share approximately 20,000 genes,” Braun says, “but scientists have little or no data for more than half of these genes.” He says that scientists around the world have been working together since 2006 to generate a targeted knockout mutation for every gene in the mouse genome. “Deleting individual genes in this way provides valuable clues to the genes’ function.”

JAX and two other NIH funded centers are part of a worldwide effort, the International Mouse Phenotyping Consortium (IMPC), to genetically and systematically determine the function of every mammalian gene, one gene at a time. The consortium is engaged in the immense task of producing and phenotyping (collecting physiological data from) these mice. Mouse models of genes with common functionality between mice and humans can lead to new models of human disease, which are useful for drug screening, preclinical studies and deeper understanding of biological and disease mechanisms.

Under the new grant, Braun says, JAX will take advantage of powerful new gene editing technology, known as CRISPR/Cas9, to generate, breed, cryopreserve and clinically assess the health and well-being of 1,000 lines of mice. The research team will work with the scientific community to select genes of exceptional interest, genes for which little is presently known, and genes predicted to function in select pathways.

For each of the new mouse lines, JAX will assess body weight and composition, metabolic and physiological parameters, and behavioral and cognitive function at several age points, and make both the mice and the resulting data available to the worldwide scientific community prior to publication.

Advertisement