Lorus Announces a Cooperative Research and Development Agreement with National Cancer Institute
News May 25, 2009
Lorus Therapeutics Inc. has announced extension of a cooperative research program with the U.S. National Cancer Institute (NCI), National Institutes of Health (NIH), which includes its Ribonucleotide Reductase (RNR) targeted RNA-targeted drugs.
Under a Materials Cooperative Research and Development Agreement (MCRADA), the Laboratory of Cancer Biology & Genetics (LCBG) of the NCI will use Lorus' LOR-2501 and LOR-2040, and LOR-1284, in combination with commercially-available drugs, to develop a drug cocktail(s) that is more effective for the treatment of Renal Cell Carcinoma tumors than for normal regenerating kidney. Of specific interest in this regard is the potential usage of this anti-tumor treatment approach in targeting the tumor and not the normal regenerating tissue.
The title of the MCRADA is "Renal Cell Carcinoma as Wounds that do not heal: Drug Combinational Therapy using Lorus Therapeutics' Antisense Oligonucleotides to Ribonucleotide Reductase M1 Polypeptide (RRM1) & RRM2, and siRNA to RRM2". The studies are being conducted at the NCI by Dr. Joseph Riss and the NIH Principal Investigator Dr. Glenn Merlino.
All three drugs that are being evaluated in this cooperative research program have emerged from Lorus' oncology drug discovery program and have been extensively tested in many preclinical models. LOR-1284 is currently in preclinical development as the Lorus' lead siRNA drug targeting RRM2. LOR-2501 and LOR-2040, the Lorus' lead antisense drugs targeting RRM1 and RRM2 respectively, are each in clinical development stage with the primary focus at present on the LOR-2040 Phase II program in Acute Myeloid Leukemia, among several cancer indications studied.
"This MCRADA is an example of the ongoing collaborative research that Lorus strives to undertake in parallel with each of its developmental programs", said Dr. Aiping Young, Lorus' President and CEO. "Such partnership accelerates the knowledge generated by research activities into practical applications and provides a basis for future development opportunities over and above our core development program".
Cancer Cells’ Energy Source Blocked by Natural CompoundNews
Researchers have not only untangled an unusual wiring system that cancer cells use for carbohydrate metabolism, but also identified a natural compound that appears to selectively shut down this system in laboratory studies.READ MORE
The Ancient Behaviour of Sleep, Conserved Throughout EvolutionNews
The finding that jellyfish sleep implies that sleep is an ancient behavior, largely untouched by millennia of evolution.READ MORE
Gene Immunotherapy Approach Prevents and Reverses Symptoms of Multiple SclerosisNews
Researchers used a viral vector to deliver a gene encoding a myelin sheath protein to the liver, thereby inducing robust and durable immune tolerance in mice by preventing T cells from attacking the myelin sheath.READ MORE