miRNA Regulated Networks Identified in Cystic Fibrosis
News May 21, 2013
Integrated DNA Technologies (IDT) offers insight into recent research that has unearthed an miRNA-regulated network implicated in the pathogenesis of Cystic Fibrosis (CF). Described in the April edition of DECODED, the international IDT customer newsletter, optimized DIG-labeled DsiRNAs (IDT) were used to develop a novel, enhanced approach for oligonucleotide delivery. Using this delivery technology, researchers led by Dr Paul McCray and Dr Beverly Davidson (Department of Pediatrics, Carver College of Medicine, University of Iowa, IA, USA) showed that the introduction of an miR-138 mimic, developed by IDT, resulted in knockdown of the transcriptional regulator SIN3A, subsequently leading to improved CFTR anion channel functionality on the cell surface, and a partially rescued phenotype.
The discovery sheds light on a previously unrecognized mechanism of CFTR processing, and opens up exciting possibilities for novel therapeutic targets in CF. Dr McCarthy commented on the strength of the collaboration with IDT, observing how the quality of the oligos remained intact for the entirety of the experiments, and provided them with “a really robust tool to look at the questions we were asking”.
Genomics Researchers Showcase their Applications of Droplet Digital PCR at ASHG 2017 Annual MeetingNews
The sensitivity and reliability of Droplet Digital PCR will be showcased in over a dozen presentations at the American Society of Human Genetics (ASHG) 2017 Annual Meeting.READ MORE
Biomarker for Glioblastoma Predicts Clinical Course and Sensitivity to TreatmentNews
Scientists validate a biomarker indicative of patients with Glioblastoma prognosis and likely response to specific therapies.READ MORE
BC Platforms Announces Collaborations in Multiple Sclerosis ResearchNews
Company's technology and research platforms used to better understand genetic basis of MS.READ MORE
Comments | 0 ADD COMMENT
Annual Conference on Antimicrobials and Drug Resistance
Sep 24 - Sep 25, 2018
1st Alpine Winter Conference on Medicinal and Synthetic Chemistry
Jan 28 - Feb 01, 2018