Nastech Presents Results on RNAi Program for Treatment of Rheumatoid Arthritis
News Nov 23, 2005
Nastech Pharmaceutical Company Inc. has announced the presentation of data from its RNA interference therapeutic program for rheumatoid arthritis at the American College of Rheumatology Annual Scientific Meeting.
The presentation titled "Development of siRNAs Targeting Human Tumor Necrosis Factor Alpha (TNF-alpha) for the Treatment of Rheumatoid Arthritis" included information resulting from collaboration with Mayo Validation Support Services.
Nastech's proprietary RNAi therapeutic formulations were screened for the ability to halt the production of TNF-alpha, a protein that is over-expressed in rheumatoid arthritis and other chronic inflammatory diseases.
Results demonstrated that Nastech's proprietary RNAi therapeutics were able to significantly reduce TNF-alpha levels in cells from patients with rheumatoid arthritis.
The study also profiled TNF-alpha messenger RNA and protein levels in rheumatoid arthritis patients who are currently on the approved therapies.
Such patients were unexpectedly shown to have elevated TNF-alpha messenger RNA in their immune cells and TNF-alpha protein in their blood.
"This study confirms that there are actually increased TNF-alpha levels in patients with rheumatoid arthritis who are currently being treated with therapies which are described as TNF-alpha inhibitors," stated Steven C. Quay, M.D., Ph.D., Chairman, President and CEO of Nastech.
"This evidence and the demonstration that our RNAi therapeutic significantly reduced the TNF-alpha levels in patients' immune cells supports the idea that the effect of RNAi is distinctively different from that of the approved therapies, and may provide a more effective treatment option."
Bioethics Council Rules Heritable Genome Editing "Ethically Acceptable" In Certain CircumstancesNews
A leading UK bioethics advisory body has weighed in on the debate around human genetic modification, concluding that heritable genome editing – modifying the DNA of an egg, sperm or embryo with changes that will be passed on to future generations – could be ‘morally permissible’ in humans, provided key ethical tests are met.
Hay Fever Risk Genes Overlap with Autoimmune DiseaseNews
In a large international study involving almost 900,000 participants, researchers from the University of Copenhagen and COPSAC have found new risk genes for hay fever. It is the largest genetic study so far on this type of allergy, which affects millions of people around the world.READ MORE
Hidden Signals in RNAs Regulate Protein SynthesisNews
Scientists have long known that RNA encodes instructions to make proteins. In a new study published in Nature, scientists describe how the protein-making machinery identifies alternative initiation sites from which to start protein synthesis.READ MORE