NCBI Adopts Standard for Accepting 454's Sequencing Data
News Jan 30, 2006
454 Life Sciences Corporation, a subsidiary of CuraGen Corporation has announced that the National Center for Biotechnology Information (NCBI) has added a standard submission format for its Trace Archive of sequencing data.
Data generated with 454 Life Sciences' technology can now be directly entered into the Trace Archive.
Sequence trace data generated with 454 Life Sciences' technology is submitted in a format called Standard Flowgram Format (SFF) and represents the first sequence trace format adopted by the NCBI since the Sanger method.
"The woolly mammoth DNA we recently sequenced at Penn State represents the first genomic data submitted to the NCBI database in the 454 Life Sciences' format," stated Stephan C. Schuster, Associate Professor at Penn State's Center for Comparative Genomics and Bioinformatics.
"We are delighted with the Genome Sequencer 20 System and its ability to rapidly perform DNA sequencing on samples, which could not previously be sequenced, and the ability to submit the sequencing data directly to the Trace Archive."
"The submission of our sequencing data allowed for the results to be publicly available prior to the publication of our article in the peer-reviewed journal, Science."
"Today's announcement underscores 454 Life Sciences' commitment to working cooperatively with the academic community to facilitate genetic research and the open exchange of sequence information," stated Christopher K. McLeod, President and Chief Executive Officer of 454 Life Sciences.
"We are pleased that the NCBI has adopted a standard for accepting data generated with 454 Life Sciences' Genome Sequencer 20 System into the Trace Archive."
"We hope that the extraordinary amount of data being generated with our technology will be placed into the public domain, thereby fostering research in a variety of areas including medicine, biology, and paleontology."
The Trace Archive (in collaboration with the Ensembl Trace Server) is a repository for the raw sequence data underlying genome projects.
"It is exciting that the data generated on the Genome Sequencer 20 System is in a format that can be deposited directly into the NCBI Trace Archive," stated Dr. Bruce A. Roe, George Lynn Cross Research Professor of Chemistry and Biochemistry at the University of Oklahoma.
"This will make the massive amount of data generated by this revolutionary system easily available to the scientific community."
"It is refreshing to see that 454 Life Sciences is working closely with those of us who support open data formats and improved data access."
Researchers Awarded $28M for Illuminating Druggable Genome NIH GrantsNews
Researchers receive grants as part of the NIH program focused on experimental and informatics approaches to characterize understudied proteins from three gene families: ion channels, G protein-coupled receptors (GPCRs), and protein kinases.READ MORE
No Country for Old GenesNews
Our modern world is radically different from the one we evolved in, and that creates a mismatch between the environment our genes were evolved to face, and the world those genes now encounter. A new review looks at how certain genes that benefited humans in our genetic past now predispose us to disease in old age.READ MORE
CRISPR Editing Stops HIV Virus in Infected CellsNews
Human immunodeficiency virus-1 (HIV-1) infection is a chronic disease affecting more than 35 million people worldwide. The infection can be controlled by antiretroviral therapy (ART), but there is still no complete cure. Now, a new study targeting the regulatory genes of the virus using CRISPR/Cas9 has helped block the production of the virus by infected cells.READ MORE