“We believe our discovery of BECLIN1 as a master regulator of gut health provides an important new target for further investigation into how to tackle the root causes of IBD and perhaps develop new treatments for the disease,” Associate Professor Lee said.

This research was done in collaboration with scientists from the University of Melbourne, the University of Queensland, the Garvan Institute of Medical Research, and the UK-based Francis Crick Institute and the Institute for Liver and Digestive Health.

Reference: Tran S, Juliani J, Harris TJ, et al. BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking. Commun Biol. 2024;7(1):209. doi: 10.1038/s42003-024-05890-7

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.