New Pathogen Resource Launched
News Apr 10, 2012
Launch of PhytoPath, a new resource to help researchers find ways to combat agricultural pathogens.
PhytoPath integrates genome-scale data of important plant pathogen species with literature-curated information about the phenotypes of host infection.
PhytoPath uses the Ensembl Genomes browser to provide access to complete genome assembly and gene models of agriculturally important fungal and oomycete plant pathogens.
It links genes to experimentally verified functional information on disease progression in the host using data from PHI-base, a curated resource that describes interactions between pathogens and their hosts as well as the intervention targets of commercially used anti-infective chemistries.
PhytoPath helps researchers make the most of the vast quantities of data produced in sequencing experiments, for example genomes, gene expression and sequence variation, by integrating them with curated information about infectious phenotypes.
PhytoPath also provides several analysis tools to help researchers compare predicted gene repertoires of pathogens with similar (or dissimilar) lifestyles.
Just as the 1000 Genomes Project is critical for understanding variation in human populations, studies of population-scale variation are increasingly critical to the molecular dissection of plant disease.
Insights from these studies will make it easier for researchers to divine the origins of crop diseases and devise new strategies to control them.
PhytoPath contains the genomes of many devastating pathogens, including Phytophthora infestans, which brought on the Irish potato famine of the mid-19th Century and has re-emerged as an important biotic threat to global food security.
Also included are the genomes of several cereal fungal pathogens that regularly lower global grain production by between 15 and 30%: Magnaporthe oryzae (rice and wheat blast), Puccinia graminis and P. triticina (the rusts), Blumeria graminis (powdery mildew), the wheat leaf-infecting pathogen Septoria tricitici (Mycosphaerella graminicola) and Fusarium graminearum (Gibberella zeae), a fungus which produces mycotoxins that are harmful to human and animal health.
PhytoPath also provides enhanced searching of the PHI-base resource as well as the fungi and protists in Ensembl Genomes.
To keep pace with the growing body of information in the scientific literature, a new community curation initiative will be launched in 2012.
Developed with funding from the Biotechnology and Biological Sciences Research Council (BBSRC), PhytoPath is a collaboration between the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) and Rothamsted Research in the UK.
PHI-base has been given National Capability status by BBSRC for its part in helping the UK deliver world-leading environmental research.
Single-stranded Origami Technology Drives Drug Delivery Systems and Pharmaceutical Nanofactories ForwardNews
First nanotechnological approach enables the design and replication of complex single-stranded DNA and RNA origami with potential for drug delivery and nanofabrication.READ MORE
Leibniz Supercomputing Centre Introduces Plans for its Next-generation SuperMUC MachineNews
Leadership at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences and Humanities announced today that they have signed a contract with Intel and Lenovo to build SuperMUC-NG, the next generation of the centre's leading-edge supercomputers.READ MORE
Cracking the Code of Coenzyme Q BiosynthesisNews
Coenzyme Q is a vital cog in the body’s energy-producing machinery, a kind of chemical gateway in the conversion of food into cellular fuel. Researchers are developing new tools to shed light on CoQ function, primarily by finding and defining proteins that have a direct link to the chemical. This includes the development of a new multi-omic strategy to identify the global function of an RNA-binding protein that has long been associated with mitochondria and its role in CoQ biosynthesis.READ MORE