NIAMS Funds new Centers of Research Translation
News Nov 10, 2006
Bridging the gap between bench and bedside is the goal of four new Centers of Research Translation (CORTs) funded by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health (NIH).
CORTs are designed to bring together basic and clinical research in a way that helps translate basic discoveries into new drugs, treatments and diagnostics.
The four centers are:
- Center for Translating Molecular Signal Pathways to Orthopaedic Trauma Care, headed by Randy Rosier, M.D., Ph.D., chair of orthopaedics at the University of Rochester, N.Y.
This center will study the biological basis of fracture healing and the efficacy of a potential new treatment, teriparatide, an injectable form of human parathyroid hormone that stimulates new bone formation.
- Center for Lupus Research, headed by M. Virginia Pascual, M.D., at the Baylor Research Institute in Dallas, Texas.
This CORT will study the role of different cell types in the origin and development of lupus, will develop markers of disease activity and severity, and will look for new targets for treatment.
Lupus is an autoimmune disease that can affect many parts of the body, including the joints, skin, kidneys, lungs, heart and/or brain.
- Center for X-Linked Hypophosphatemic Rickets Research, led by Thomas O. Carpenter, M.D., at Yale University in New Haven, Conn.
This center will study the various molecular contributors to this genetic form of rickets and work toward developing new treatments.
This center will study the molecular basis of scleroderma to understand its underlying causes using functional genomics and gene networks.
Studies will involve a multiethnic cohort of scleroderma patients, as well as two mouse models of fibrosis recently developed at this center.
Using EBX reagents, researchers have converted the C-terminal carboxylic acid of peptides into a carbon-carbon triple bond - an alkyne (in chemical jargon a "decarboxylative alkynylation"). The alkyne moiety is a very valuable functional group that can be used to further modify the peptides.READ MORE