Nucleis will Present its RNAi Technology
News Sep 28, 2005
Nucleis has announced that it has offered knock down (RNAi) in vivo mouse model and is currently developing alternatives for conditional and inducible in vivo knock down (RNAi) expression.
Nucleis thanks to a proprietary innovative technology called Speedy Mouse Technology which allows the generation of models in two months.
Speedy Mouse RNAi Technology is based on targeted transgenesis of short hairpin RNA construct into hprt permissive locus of proprietary ES cells, called BPES cells.
These cells demonstrate high potency to colonize wild type blastocyst leading to 100% chimeric mice with 100% germ line transmission.
Single copy integration of shRNA constructs through targeted transgenesis in BPES cells appears to be as efficient as random transgenesis but powerful in term of time, reproducibility and predictability.
Exclusive results of the efficiency, stability and inheritability of the Speedy Mouse® RNAi Technology will be presented at “RNAi Europe meeting” in Amsterdam on September 29th and later in Boston on October 18th for the 4th Annual Discovery on Target.
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.
Researchers published today a detailed description of the complete genome of bread wheat, the world's most widely-cultivated crop. This work will pave the way for the production of wheat varieties better adapted to climate challenges, with higher yields, enhanced nutritional quality and improved sustainability.