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Observing DNA’s Molecular Repair Process in Real-time

News   May 01, 2020 | Original story from the University of Konstanz

 
Observing DNA’s Molecular Repair Process in Real-time

Infrared spectra at different points of time (0-79 min) after the poly(ADP-ribosyl)ation reaction started due to the addition of PARP1 substrate NAD+. The following can be observed: the dynamic formation of the biopolymer poly(ADP-ribose) (absorption bands at 1236 cm-1 and 1074 cm-1) and the detachment of PARP1 from the DNA strand break (absorption bands at 1645 cm-1 and 1548 cm-1). Credit: Modified from Krüger et al.

 
 
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