Oncomed Pharmaceuticals and Fluidigm Corporation Announce Strategic Collaboration
News Jan 08, 2010
OncoMed Pharmaceuticals, Inc. and Fluidigm Corporation announced a new initiative to apply Fluidigm’s microfluidic tools to the analysis of tumor cell heterogeneity, including cancer stem cells.
The collaboration will combine Fluidigm’s advanced microfluidic platforms with OncoMed’s proprietary cancer stem cell sorting technology to generate tools for analyzing, quantifying and developing treatments directed at a highly tumorigenic cell population.
In the initial application, OncoMed will apply Fluidigm’s BioMark™ System along with Fluidigm’s proprietary Dynamic Array™ integrated fluidic circuits (IFCs) to perform detailed gene expression analysis of solid tumors at the whole tumor and single-cell level. This phase will track changes in cancer stem cells found in human tumors following treatment with OncoMed’s extensive pipeline of therapeutic monoclonal antibodies.
The companies will apply this same technology to analyze tumor heterogeneity and cancer stem cell frequency across OncoMed’s proprietary human tumor bank which includes approximately one hundred human tumor biopsies that have been engrafted and minimally passaged in immunocompromised mice.
The OncoMed/Fluidigm collaboration also has the potential to include novel and next-generation microfluidic and tissue sample-preparation technologies that Fluidigm is currently developing.
New Method to Separate Mirrored Molecules Could Lead to Safer DrugsNews
The Dionne lab is developing an optical filter to sort chiral molecules, which could lead to purer and safer drugs and agrichemicals.READ MORE
“Nanokicking” Technology Enables Breakthrough in the Culture of 3D Mineralised Bone TissueNews
Researchers have grown 3D samples of mineralised bone from human mesenchymal stem cells for the first time without typical osteoinductive media.READ MORE
How do Poison Frogs Protect Themselves Against Their Own Neurotoxin?News
Scientists are a step closer to resolving a related head-scratcher, how do these frogs keep from poisoning themselves?READ MORE