Pacific Bio, Advanced Analytical Collaborate
News Apr 27, 2016
The PacBio® RS II and Sequel™ Systems are based on PacBio’s proven Single Molecule, Real-Time (SMRT®) technology and are used to sequence small or large genomes, as well as to perform targeted sequencing, complex population analysis, and RNA sequencing. SMRT Sequencing provides characterization of many types of genomic variation, including those in complex regions not accessible with short-read or synthetic long-read sequencing technologies. It also reveals epigenetic information. AATI’s Fragment Analyzer™ quantifies and qualifies nucleic acid samples in one step with accurate sizing to ~50 kilobases in length. The method takes ~1 hour (as opposed to ~16 hours with pulse field gel electrophoresis) and can process up to 96 samples in parallel.
“We are excited to team with Advanced Analytical. Their Fragment Analyzer will help
streamline our large-insert library workflow for de novo assemblies, where it is important to know the size of the libraries before and after size selection,” said Kevin Corcoran, Senior Vice President of Market Development at PacBio. “Use of the Fragment Analyzer for accurate sizing will significantly speed the time it takes to make a library and improve the likelihood of project success.”
Dr. Jonathan Hagopian, Director of Business Development at Advanced Analytical, added: “We are proud that we have met PacBio’s high standards for data quality and performance with our Fragment Analyzer system. Our collaboration will accelerate discoveries based on their powerful long-read sequencing technology.”
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated.
Researchers published today a detailed description of the complete genome of bread wheat, the world's most widely-cultivated crop. This work will pave the way for the production of wheat varieties better adapted to climate challenges, with higher yields, enhanced nutritional quality and improved sustainability.